منابع مشابه
To pool, or not to pool?
Let's start with the most familiar context for pooling data (at least to students in introductory courses in statistics), viz., the pooling of sample variances in a t test of the significance of the difference between two independent sample means. The null hypothesis to be tested is that the means of two populations are equal (the populations from which the respective samples have been randomly...
متن کاملCommentary To Pool , or Not to Pool ?
IN this issue of Genetics, Futschik and Schlötterer (2010) present one of the first and the most systematic explorations of the relative merits of pooling vs. individual sequencing for several genetics applications. They argue that pooling individuals is often more effective both for SNP discovery and for the estimation of allele frequencies (and thus for population genomic analyses) and as a r...
متن کاملTo Pool or Not To Pool? Revisiting an Old Pattern
We revisit the well-known object-pool design pattern in Java. In the last decade, the pattern has attracted a lot of criticism regarding its validity when used for light-weight objects that are only meant to hold memory rather than any other resources (database connections, sockets etc.) and in fact, common opinion holds that is an “anti-pattern” in such cases. Nevertheless, we show through sev...
متن کاملIn vitro experiments with primary mammalian cells: to pool or not to pool?
There are various strategies that can be adopted when performing in vitro experiments with primary cells such as mesenchymal stem cells. It is generally accepted that multiple donors need to be investigated to take into account donor to donor variability; this is especially critical when investigating primary human cells. However, increasingly it is being seen that studies are pooling the cells...
متن کاملTo pool or not to pool DNA methylation data from different tissues?
To pool or not to pool DNA methylation data from different tissues? Sir, With great interest I read the paper of Lazaraviciute et al. (2014) in your journal. In this review, the authors show the results of a meta-analysis on imprinted gene DNA methylation effects of IVF/ICSI on the forthcoming children. With numerous studies focussing on health of IVF children and the potential risk of adverse ...
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ژورنال
عنوان ژورنال: Genetics
سال: 2010
ISSN: 1943-2631
DOI: 10.1534/genetics.110.121012